Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10791 |
CHK1-IN-3
|
Chk | Cell Cycle/Checkpoint |
CHK1-IN-3 是一种检测点激酶 (CHK1) 抑制剂,IC50 值为 0.4 nM。 | |||
T68981 |
PD-321852
|
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PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cd... | |||
T36704 |
CCT241533 dihydrochloride
CCT 241533 dihydrochloride |
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Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793 |